Mary Bethel was from Columbia, Lancaster County, Pennsylvania. She was born about 1732, the daughter of Samuel Bethel and Sarah Bethel (Blunston) and the sister of Elizabeth Bethell; William Bethel; Edward Bethell; Samuel Bethel, II and Sythe Hammett. In 1717, her grandfather William Bethel bought about 100 acres on the Conestoga Creek near Lancaster City, & in 1730 he was licensed to keep a public-house or a tavern in Lancaster city. Between 1737-38, he was Lancaster County treasurer. At the age of 17, Mary married Dr.Samuel Boude,an eminent physician & druggist, and was the mother of Gen. Thomas Boude; Sarah Bethel Barber; Mary Bethel Barber: Elizabeth Lewis; Henrietta Boude and 2 others. She died after 1761.